The impact of anti-SSA/Ro antibodies on pregnancy outcomes in patients with systemic lupus erythematosus - PubMed
6 hours ago
- #systemic lupus erythematosus
- #anti-SSA/Ro antibodies
- #pregnancy outcomes
- Study investigates the impact of anti-SSA/Ro antibodies on adverse pregnancy outcomes (APOs) in systemic lupus erythematosus (SLE) patients.
- Data was extracted from the Lupus Registry of Nationwide Institutions (LUNA, 2016-2022) involving 1775 pregnancies, with 247 pregnancies analyzed after exclusions.
- Fetal loss was associated with antiphospholipid antibodies (aPL) and a history of methylprednisolone pulse, but not with anti-SSA/Ro antibodies.
- No significant differences were found between anti-SSA/Ro positive and negative groups in terms of live birth or preterm birth rates.
- Anti-SSA/Ro antibodies may influence fetal development, but further research is needed to confirm this.
- aPL showed a significant association with fetal loss in SLE patients.