Unraveling allosteric signaling of G protein-coupled receptors (GPCRs) by single-molecule fluorescence - PubMed
5 hours ago
- #Allostery
- #GPCRs
- #Single-Molecule Fluorescence
- GPCRs are the largest family of membrane receptors in eukaryotes, central to many physiological processes and diseases.
- Allostery is crucial for GPCR function, facilitating signal transmission across membranes.
- Key allosteric phenomena in GPCR signaling include ligand efficacy, biased signaling, and allosteric modulation.
- Single-molecule fluorescence techniques, especially smFRET and smPIFE, have advanced understanding of GPCR allostery.
- These techniques help address gaps in knowledge and could aid in developing more effective and selective therapeutics.