SLC22A3/OCT3 drives serotonin-mediated stemness in pancreatic cancer - PubMed
5 hours ago
- #serotonin signaling
- #pancreatic cancer stem cells
- #SLC22A3/OCT3
- SLC22A3/OCT3 is upregulated in CSC-enriched populations and regulates pancreatic cancer stemness.
- Silencing SLC22A3 reduces key stemness features in 2D and 3D PC models.
- SLC22A3 mediates serotonin transport, enhancing stemness via downstream histone modifications.
- SLC22A3 is identified as a potential therapeutic target in pancreatic cancer.