Long COVID neuropathy: The role of mast cells - PubMed
5 days ago
- #Mast Cells
- #Long COVID
- #Neuropathy
- Long COVID affects over 60 million people globally, with symptoms like neuropathic pain, fatigue, and autonomic dysfunction.
- Mast cells (MCs) play a central role in neuropathic manifestations of Long COVID due to their location near nerves and vessels.
- SARS-CoV-2 spike protein activates MCs via ACE2 and TLR4, releasing pro-inflammatory and neurotoxic mediators.
- These mediators contribute to small-fiber injury, neuroinflammation, and dysautonomia.
- MC-directed treatments show variable benefits, suggesting potential for targeted therapies in Long COVID neuropathy.