Acute Inflammation Drives Corneal Pathological Regeneration - PubMed
6 hours ago
- #regenerative pathology
- #corneal inflammation
- #single-cell genomics
- The study characterizes transcriptional and epigenetic changes in the cornea caused by acute inflammation using scRNA-seq and scATAC-seq.
- Sixteen cell clusters were identified, including epithelial subpopulations and immune cells such as neutrophils and macrophages.
- Inflammation inhibits limbal stem/progenitor cell differentiation and reveals cell-type-specific gene regulatory elements.
- Intercellular communication signals among all cell types were analyzed, providing insights into corneal pathological regeneration.