ZBP1-driven pyroptosis-associated alveolar macrophages exacerbate epithelial dysfunction in sepsis - PubMed
4 hours ago
- #Pyroptosis
- #Sepsis
- #Alveolar Macrophages
- ZBP1 drives macrophage pyroptosis, exacerbating inflammation and epithelial dysfunction in sepsis-induced acute lung injury.
- ZBP1 deficiency reduces macrophage pyroptosis and inflammatory signaling, mitigating alveolar epithelial cell injury.
- Targeting ZBP1 could restore immune-epithelial homeostasis and prevent organ failure in sepsis.