Emphysema severity-associated gut microbiota modulates smoke-induced emphysema: evidence from fecal microbiota transplantation - PubMed
4 hours ago
- #gut microbiota
- #fecal microbiota transplantation
- #emphysema
- The study investigates whether differences in gut microbiota and metabolites contribute to varying emphysema severity in smokers via the gut-lung axis.
- Gut microbiota and metabolites differed significantly among non-emphysema, non-severe emphysema, and severe emphysema groups in 78 participants.
- Severe emphysema patients had lower acetic acid levels, while non-emphysema individuals showed higher abundance of Prevotellaceae and Megasphaera.
- Fecal microbiota transplantation (FMT) from severe emphysema donors worsened lung pathology in smoke-exposed mice, whereas FMT from non-emphysema donors attenuated emphysema development.
- The findings suggest gut microbiota influences emphysema progression and could be a therapeutic target for chronic obstructive pulmonary disease.