Dynamic association between triglyceride-glucose-body mass index and hospital mortality in critically ill patients with heart failure: a multicenter retrospective cohort study - PubMed
5 hours ago
- #Heart Failure
- #Insulin Resistance
- #Critical Care
- The study examines the association between triglyceride-glucose-body mass index (TYG-BMI) and hospital mortality in critically ill heart failure (HF) patients.
- TYG-BMI shows a non-linear U-shaped dose-response relationship with mortality, with optimal range between 250-275.
- Higher TYG-BMI (>425) is associated with progressively increased mortality risk, amplified over time.
- Combining TYG-BMI with SOFA score improves discriminative performance for mortality prediction.
- The study is a multicenter retrospective analysis using MIMIC-III, MIMIC-IV, and eICU databases.
- Findings suggest both intensity and duration of TYG-BMI exposure contribute to risk stratification.
- Prospective validation is needed due to the observational design and uncertain physiological specificity in ICU settings.