Targeting genomic instability in cancer - PubMed
5 hours ago
- #Cancer Therapeutics
- #DNA Damage Response
- #Genomic Instability
- Genomic instability is a key feature of cancer, resulting from failures in DNA maintenance systems that allow genetic changes driving cancer.
- Targeting genomic instability has evolved from chemotherapy and radiation to PARP inhibitors for HR-deficient tumors, and now includes ADCs and radiopharmaceuticals.
- Precision medicine strategies aim to optimize patient selection, develop combination therapies, and improve the therapeutic index.
- Multiple authors have conflicts of interest, including employment, commercial interests, funding, and consultancy roles with various pharmaceutical and biotech companies.