Targeting Glycolytic Metabolism in Cancer Therapy: Current Approaches and Future Perspectives - PubMed
6 hours ago
- #glycolysis inhibitors
- #Warburg effect
- #cancer therapy
- Targeting the Warburg effect (aerobic glycolysis) in tumor cells is a promising metabolic therapeutic strategy in cancer research.
- Key glycolysis pathway components include glucose transporters (GLUTs) and glycolytic enzymes like HK2, PFK, GAPDH, PKM2, and LDHA.
- Current inhibitors face limitations due to tumor metabolic plasticity and toxicity concerns in normal cells.
- Synergistic interactions between glycolysis inhibitors and other therapies (chemotherapy, radiotherapy, immunotherapy, etc.) may improve efficacy and overcome resistance.
- Future challenges include selective inhibition of glycolytic enzymes in cancer cells, requiring high-selectivity agents, nanodelivery systems, and biomarker identification.