PARP7 protects the lung epithelial barrier from diverse environmental threats - PubMed
5 hours ago
- #lung epithelial barrier
- #PARP7
- #AHR
- PARP7 is crucial for maintaining lung epithelial barrier integrity.
- Loss of PARP7 in mice leads to increased susceptibility to diffuse alveolar hemorrhaging (DAH) and lupus.
- PARP7 is selectively expressed in alveolar type I cells; its loss increases immune cell infiltration in the lungs.
- PARP7 inhibition in human bronchial epithelial cells results in higher barrier permeability after cigarette smoke or bacterial infection.
- PARP7 targets the aryl hydrocarbon receptor (AHR), influencing responses to cigarette smoke, including tight junction protein Occludin loss and increased proinflammatory gene expression.
- The study highlights PARP7's role in lung physiology, with implications for pulmonary diseases and PARP7 inhibitor use in clinical settings.