Elevated microbially-derived metabolites in autism: a possible diagnostic screening test for a distinct ASD phenotype - PubMed
4 hours ago
- #Gut-Brain Axis
- #Diagnostic Screening
- #Autism Spectrum Disorder
- Elevated microbially-derived metabolites (MDMs) are found in many children with autism spectrum disorder (ASD), with urinary concentrations sometimes 100-1000 times higher than in typically developing children.
- The study involving 52 ASD and 47 typically developing children identified significantly higher levels of MDMs—derived from phenylalanine, tryptophan, and yeast—in the ASD group, suggesting a distinct ASD sub-phenotype linked to gut dysbiosis.
- Using the MDM System™ for diagnostic screening, the presence of one or more elevated MDMs achieved 90% sensitivity and 100% specificity in classifying ASD in children aged 2 to 11.
- Approximately 90% of children with ASD may have a phenotype termed ASD associated with Microbially-Derived Metabolites (ASD-MDM), defined by quantifiable MDM levels in urine, offering a non-invasive screening method.