Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets - PubMed
3 hours ago
- #multi-omics profiling
- #acute myeloid leukemia
- #therapeutic targets
- The study applied a multi-omics approach (13 modalities) to 173 treatment-naive AML patients to identify molecular subtypes and therapeutic targets.
- Integration of proteogenomic and metabolomic data revealed AML subtypes with distinct metabolic reprogramming driven by MYC and mTOR activity.
- Hyperacetylation of mitochondrial proteins was specifically linked to CEBPA-mutant AML, highlighting genotype-phenotype associations.
- Protein-centric subtyping identified a unique NPM1-mutant subset characterized by outlier expression of FOXC1 and HOXB8/9.
- A multi-omic machine-learning approach nominated MTA1 as a therapeutic target contributing to panobinostat resistance across subtypes.