Characteristic patterns of complement deposition in NMOSD, MOGAD, and MS - PubMed
2 months ago
- #pathogenesis
- #inflammatory demyelinating diseases
- #complement system
- The complement system plays a role in inflammatory demyelinating diseases (IDDs) of the CNS.
- Complement inhibition reduces relapse rates in neuromyelitis optica spectrum disorders (NMOSDs).
- In NMOSD, complement deposition shows a perivascular rosette/rim pattern in astrocyte-lytic lesions.
- MOGAD exhibits C4d deposition around perivenous demyelinating lesions in 83% of tissues.
- MOGAD has two types: Type A with limited C9neo deposition and preserved oligodendrocytes, and Type B with strong C9neo deposition and oligodendrocyte loss.
- Type B MOGAD pathology is more common in deceased patients, while Type A is prevalent in living patients.
- In MS, C4d deposits are found on myelin sheaths in peri-plaque white matter, decreasing with lesion activity.
- Complement deposition in MS lesions correlates with a shorter interval between disease onset and death.
- Distinct complement deposition patterns in NMOSD, MOGAD, and MS reflect their different pathogeneses.