O-GlcNAcylation of IGF2BP2 promotes angiogenesis after ischemic stroke by stabilizing PPP2CA in an m6A-dependent manner : O-GlcNAcylation of IGF2BP2 alleviates ischemic brain injury - PubMed
4 hours ago
- #ischemic stroke
- #angiogenesis
- #O-GlcNAcylation
- O-GlcNAcylation of IGF2BP2 at serine 162 stabilizes the protein by inhibiting its ubiquitination and degradation.
- Stabilized IGF2BP2 promotes angiogenesis after ischemic stroke by stabilizing PPP2CA in an m6A-dependent manner.
- IGF2BP2 upregulates PPP2CA, which reduces YAP phosphorylation and promotes its nuclear translocation, activating the Hippo/YAP signaling pathway.
- This mechanism alleviates brain injury in MCAO/R rats and OGD/R-induced BMEC injury.
- The study highlights the therapeutic potential of targeting IGF2BP2 O-GlcNAcylation for ischemic stroke treatment.