Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macrophages - PubMed
5 hours ago
- #Efferocytosis
- #Tumor Microenvironment
- #Macrophage Reprogramming
- Efferocytosis leads to proangiogenic functions in macrophages and changes their chromatin structure.
- Researchers developed Effero-seq to study single-cell transcriptomic changes and lysosomal acidification after efferocytosis.
- In a melanoma model, macrophages near blood vessels showed proangiogenic activity due to efferocytosis.
- Efferocytosis altered chromatin accessibility, reducing macrophage response to interferon-γ.
- High effero-score expression in human uveal melanoma is linked to worse survival outcomes.
- Effero-seq provides insights into macrophage reprogramming in tumors, aiding potential therapeutic developments.