Modifiable risk factors and risk of schizophrenia and bipolar disorder across severities of genetic risk - PubMed
5 hours ago
- #modifiable risk factors
- #bipolar disorder
- #schizophrenia
- Higher Brain Care Score (BCS), which includes 12 modifiable physical, lifestyle, and social-emotional factors, is associated with reduced risk of schizophrenia (SCZ) and bipolar disorder (BD), but the protective effect varies by genetic risk level.
- In individuals with low polygenic risk scores (PRS), higher BCS significantly lowers SCZ and BD risk, with strong protective effects from lifestyle and social-emotional domains.
- For those with high genetic risk (high PRS), the overall BCS protection against SCZ is not significant, but the social-emotional domain remains protective for both SCZ and BD across all genetic risk levels.
- The study, based on UK Biobank data with 299,665 participants, suggests that improving social-emotional health is a key preventive measure for SCZ and BD, regardless of genetic predisposition.