Heterogeneity and prognostic significance of mast cell subsets in the tumor microenvironment of prostate cancer - PubMed
5 hours ago
- #Mast Cells
- #Tumor Microenvironment
- #Prostate Cancer
- Prostate cancer (PC) is a high-incidence and high-mortality malignancy in men.
- Mast cells in the tumor microenvironment (TME) play dual roles in PC progression and prognosis.
- Single-cell RNA sequencing (scRNA-seq) and bioinformatics analyses identified two distinct mast cell subsets in PC TME.
- Mast cell1 subset is associated with pro-tumorigenic pathways and poorer survival outcomes.
- Mast cell2 subset exhibits antitumor immune regulatory properties and better survival outcomes.
- Key marker genes BIRC3 (unfavorable prognosis) and FOS (favorable prognosis) were identified.
- Findings provide potential molecular targets for diagnosis, prognosis, and personalized therapy in PC.