Hydrogen reshapes the senescent microenvironment of callus to enhance the healing of anti-osteoporotic-drug-induced atypical femoral fracture - PubMed
2 days ago
- #Bone Healing
- #Atypical Femoral Fracture
- #Hydrogen Therapy
- Long-term bisphosphonates (BPs) used for osteoporosis can lead to atypical femoral fractures (AFFs) with impaired healing.
- A local pro-senescent microenvironment in AFFs causes persistent inflammation and hinders regeneration.
- Treatment with hydrogen-rich water (HRW) promoted callus bridging and resolved non-union gaps in a rat AFF model.
- HRW did not compromise the bone mechanical strength improved by BPs and attenuated the senescent microenvironment.
- HRW reduced senescence markers (SA-β-gal, p16, p21), cleared pathological fibroblasts, and shifted macrophages from M1 to M2.
- HRW also rebalanced cytokines and restored formation of type-H vessels, facilitating healing without boosting systemic bone formation.