A tumor-resident bacterium promotes cervical cancer progression through lysoPC-mediated c-Jun/c-Fos activation - PubMed
5 days ago
- #microbiota
- #lysoPC
- #cervical cancer
- Tumor-resident microbiota play a critical role in cervical cancer progression.
- Patients with cervical cancer show increased microbiota diversity with eight distinct bacterial species.
- Gordonia polyisoprenivorans GP-2, a tumor-resident bacterium, promotes cervical cancer growth and metastasis in mice.
- GP-2 metabolizes host-derived choline to produce lysophosphatidylcholine (lysoPC).
- LysoPC activates tumorigenic genes c-Jun/c-Fos in cervical tumor organoids.
- The study highlights a potential therapeutic target in tumor-resident bacteria for cervical cancer intervention.