Immunomodulation by systemic administration of exosomes derived from induced pluripotent stem cell mesenchymal stem cells to alleviate liver inflammation and fibrosis in Wilson's disease - PubMed
6 hours ago
- #Liver fibrosis
- #Immunomodulation
- #Exosomes
- Exosomes from iPSC-derived MSCs show therapeutic potential for Wilson's disease (WD).
- Systemic administration of iPSC-MSC-Ex reduced liver injury and fibrosis in ATP7B knockout mice.
- Treatment improved liver function, decreased collagen accumulation, and reduced inflammation.
- iPSC-MSC-Ex modulated immune response by reducing inflammatory monocytes and NK cells while increasing Treg cells.
- Macrophage polarization was altered, leading to down-regulation of proinflammatory cytokines and up-regulation of anti-inflammatory cytokines.
- Results suggest iPSC-MSC-Ex could serve as a cell-free therapy for WD and other chronic liver diseases.