RSRC2 is a novel RNA-binding protein that safeguards mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1 - PubMed
7 hours ago
- #mitotic fidelity
- #RNA-binding protein
- #centrosome biogenesis
- RSRC2 is a novel RNA-binding protein essential for proper cell division.
- RSRC2 interacts with the long ncRNA C1QTNF1-AS1 to safeguard mitotic fidelity.
- Loss of RSRC2 or C1QTNF1-AS1 leads to mitotic defects.
- RSRC2 associates with proteins involved in splicing and centrosome biogenesis.
- RSRC2 regulates mitotic gene splicing and maintains centriole integrity.
- Depletion of RSRC2 impairs recruitment of centrosomal scaffold proteins PCNT and CDK5RAP2.
- C1QTNF1-AS1 directs RSRC2 to the centrosome, promoting PCNT mRNA recruitment.
- The study highlights RNA-protein complexes' role in error-free mitosis.