CAFs-derived LAM332 promotes CTCs formation and survival via ITGA3 and contributes to the metastasis of pancreatic ductal adenocarcinoma - PubMed
5 hours ago
- #Stromal-Tumor Interaction
- #Pancreatic Cancer Metastasis
- #Circulating Tumor Cells
- ITGA3 drives circulating tumor cell (CTC) generation and metastasis in pancreatic ductal adenocarcinoma (PDAC).
- Cancer-associated fibroblasts (CAFs) secrete laminin-332 (LAM332), which activates ITGA3 on PDAC cells to promote proliferation, invasion, CTC clustering, and survival.
- Targeting the CAFs-LAM332-ITGA3 axis reduces metastasis and improves survival in preclinical models.