Glucagon-like peptide 1 receptor agonist use and risk of arthroplasty for knee osteoarthritis: retrospective database analysis - PubMed
5 hours ago
- #GLP-1 receptor agonists
- #knee osteoarthritis
- #total knee arthroplasty
- GLP-1 receptor agonists (GLP-1 RAs) use associated with reduced risk of total knee arthroplasty (TKA) for knee osteoarthritis in a retrospective database analysis.
- Study used TriNetX Global Research Network, comparing GLP-1 RA users (any or new-generation like semaglutide/tirzepatide) with propensity score matched non-users.
- Findings show significant lower cumulative TKA incidence across all exposure classes and durations, with greater reductions for new-generation agents and longer treatment (3 years).
- Absolute risk difference at 8 years: -2.80 percentage points for any GLP-1 RA with 1-year exposure; -4.71 percentage points for new-generation agents with 3-year exposure.
- Results suggest potential disease-modifying effects beyond weight loss, though prospective trials are needed to confirm causality and optimal treatment.