Regenerative therapeutics for chronic obstructive pulmonary disease - PubMed
5 hours ago
- #regenerative medicine
- #COPD
- #lung repair
- Chronic obstructive pulmonary disease (COPD) is a common lung disease characterized by accelerated loss of lung function and defective tissue repair.
- Current therapies do not modify disease progression, necessitating new regenerative approaches.
- Preclinical and clinical studies explore small molecules (e.g., retinoids) and advanced therapies (e.g., cell therapies, extracellular vesicles) to restore lung repair.
- Challenges include variable results, clinical development hurdles (e.g., outcomes, administration routes, formulation), and targetable mechanisms like cellular senescence and chronic inflammation.
- Regenerative strategies aim for disease modification and long-term lung function restoration.