Structural basis of PSCC1 in Drosophila melanogaster: A neurotransmitter-independent pLGIC - PubMed
4 hours ago
- #Drosophila
- #pLGIC
- #Cryo-EM structure
- The study reports the cryo-EM structure of Drosophila melanogaster PSCC1 at 3.04 Å resolution.
- PSCC1 is a neurotransmitter-independent pLGIC activated by alkaline pH, important for osmotic balance and growth in insects.
- The structure shows a canonical pentameric architecture but with a drastically altered neurotransmitter-binding pocket, explaining its ligand-independent gating.
- Comparative analyses reveal distinct structural features in both the ECD and TMD, highlighting PSCC1's unique architecture within the pLGIC superfamily.
- The findings provide insight into PSCC1's function in insect physiology and a framework for understanding non-canonical invertebrate pLGICs.