Cancer-associated fibroblasts as key regulators of lipid metabolism in the tumour microenvironment - PubMed
5 hours ago
- #Cancer-associated fibroblasts
- #Lipid metabolism
- #Tumor microenvironment
- Cancer-associated fibroblasts (CAFs) are key regulators of lipid metabolism in the tumor microenvironment (TME).
- CAFs can produce, secrete, and internalize lipids, and undergo fatty acid oxidation, influencing tumor progression.
- Different CAF subtypes have opposing roles in lipid metabolism across various cancer types.
- External factors like obesity and high-fat diets impact metabolic pathways in CAFs and cancer cells.
- Understanding these metabolic pathways could lead to novel cancer treatment strategies.
- This review explores CAF lipid metabolism's role in tumor progression and treatment resistance.