Targeting the gut-joint axis: an oral Spirulina hydrogel as an adjuvant strategy for rheumatoid arthritis therapy - PubMed
5 hours ago
- #Spirulina hydrogel
- #gut-joint axis
- #rheumatoid arthritis
- RA is associated with gut barrier dysfunction and microbiota imbalance.
- An oral Spirulina-based hydrogel (SP-gel) was developed with gastric retention and intestinal sustained release properties.
- SP-gel restored intestinal barrier integrity and reduced inflammation in vitro and in vivo in mice with collagen-induced arthritis.
- When combined with hyaluronic acid, SP-gel improved joint inflammation, bone erosion, and cartilage degradation.
- Mechanisms include strengthening the gut barrier, balancing Treg/Th17 cells, and reshaping gut microbiota.
- SP-gel demonstrated safety and boosted methotrexate effectiveness, highlighting its potential as an oral adjuvant RA therapy targeting the gut-joint axis.