Altered SIgA-targeting of gut microbiota is associated with long-term dysbiosis in pediatric solid organ transplant recipients - PubMed
5 hours ago
- #SIgA
- #pediatric transplantation
- #gut microbiota
- Pediatric solid organ transplant (SOT) recipients exhibit gut microbiota (GM) dysbiosis, associated with long-term survival and influenced by immunosuppression.
- Secretory IgA (SIgA) levels are higher in SOT recipients compared to healthy controls, with altered bacterial targeting and spectra linked to dysbiosis severity.
- Tacrolimus (TAC) levels correlate with the degree of GM dysbiosis, but in vitro experiments show no direct drug effects on fecal communities.
- A proposed mechanistic model suggests GM dysbiosis in SOT is mediated by the immune system through SIgA responses, rather than direct drug actions.
- The study highlights SIgA's role in governing dysbiosis in SOT, offering insights into factors behind persistent microbial imbalances post-transplant.