Fatty acid regulation of feeding in Caenorhabditis elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system - PubMed
5 hours ago
- #GLP-1-like signaling
- #fatty acid regulation
- #feeding behavior
- C. elegans regulates feeding via a balance of saturated and monounsaturated fatty acids, affecting lipid synthesis pathways like CREB and AMPK.
- This fatty acid regulation acts through ER phospholipids and the IRE-1 sensor, influencing neuronal serotonin and the PDF-1/PDFR-1 peptide/receptor system.
- The PDF-1/PDFR-1 pair may be an ancestral precursor to GLP-1/GIP peptides, with a PDF-1-derived peptide reducing weight and improving insulin sensitivity in mice.
- In worms, this pathway triggers 'food-apathy' behaviors like food-leaving and roaming, mirroring effects of GLP-1/GIP-related peptides in humans.