Synthetic lethality between RB-loss and E2F3 inhibition in small cell cancers targeted by pyrimidine synthesis blockade - PubMed
5 hours ago
- #small cell cancer
- #RB inactivation
- #synthetic lethality
- Synthetic lethality between RB-loss and E2F3 inhibition is identified in small cell cancers.
- E2F3 dependency is linked to RB inactivation, a common feature in small cell cancers.
- E2F3 inhibition in RB-deficient cells restrains cell cycle progression, proliferation, and tumor growth.
- Inhibition of de novo pyrimidine synthesis limits E2F3 expression and suppresses small cell carcinoma proliferation.
- Targeting E2F3 presents a potential treatment strategy for RB-deficient small cell cancers.