AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling - PubMed
2 days ago
- #Lipid Remodeling
- #Immunotherapy
- #Ferroptosis
- AGPAT3 enhances tumor cell vulnerability to IFNγ-mediated ferroptosis.
- IFNγ activates IRF1, which upregulates AGPAT3, leading to lipid remodeling.
- Lipid remodeling increases polyunsaturated ether phospholipids, boosting ferroptosis sensitivity.
- AGPAT3 loss impairs IFNγ-mediated tumor elimination in vitro and in vivo.
- Higher AGPAT3 expression correlates with better immune activation and survival in ICI-treated patients.
- The IFNγ-IRF1-AGPAT3 axis is a key antitumor mechanism promoting ferroptosis.
- Combining ferroptosis-driver model prediction with AGPAT3 targeting may improve ICI efficacy.