Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease - PubMed
3 months ago
- #Alzheimer's disease
- #Neurotrophic signaling
- #Cardiac dysfunction
- Amyloid β (Aβ) pathology in Alzheimer's disease (AD) may impair cardiac neurotrophic signaling, leading to heart dysfunction.
- Tg2576-AD mice show myocardial fibrosis, Aβ deposition, and neurotrophic deficiencies, causing myocardial denervation and cardiac dysfunction.
- Aβ oligomers reduce BDNF expression in human cardiomyocytes by disrupting TrkB/CREB signaling.
- Human AD post-mortem left ventricular tissue confirms findings from cell and animal studies.
- The study identifies a potential link between AD pathology and heart degeneration through impaired brain-heart axis neuro-signaling.