Rab14 restricts pathogens by promoting V-ATPase lysosomal delivery to drive lysosomal acidification - PubMed
5 hours ago
- #lysosomal acidification
- #host-directed therapy
- #Rab14
- Rab14 is identified as a host restriction factor with broad-spectrum activity against multiple bacteria and viruses.
- Rab14 promotes lysosomal acidification by facilitating V-ATPase trafficking to lysosomes, aiding in pathogen clearance.
- The Rab14-CAMK2D-V-ATPase axis is a newly discovered intrinsic immune mechanism.
- This mechanism could serve as a promising target for host-directed therapy (HDT) against drug-resistant pathogens.
- The study highlights the importance of lysosomal acidification in clearing pathogens and combating infections.