A pH/ROS dual-responsive metal-polyphenol-antibiotic nano-assembly for combating persistent infection by overcoming biofilm and cell membrane barriers - PubMed
21 hours ago
- #Immunomodulation
- #Nanoparticles
- #Biofilm Disruption
- Nano-assembly combines Zn2+, tannic acid, and minocycline for high drug loading via coordination, hydrogen bonding, and π-π stacking.
- Dual-responsive to acidic pH and high ROS in infectious microenvironments, enabling biofilm disruption and bacterial elimination.
- Penetrates cell membranes, facilitates lysosomal escape, and delivers active components to clear intracellular bacteria.
- Modulates immunity by scavenging ROS, suppressing NF-κB signaling, and inhibiting M1 macrophage polarization to reduce inflammation.
- Promotes periodontal regeneration in vivo, integrating biofilm disruption, intracellular clearance, and immune regulation.