Urine-derived stem cell extracellular vesicles promote recovery from acute kidney injury in mice and human kidney organoids - PubMed
4 hours ago
- #urine-derived stem cells
- #acute kidney injury
- #extracellular vesicles
- Extracellular vesicles from urine-derived stem cells (USC-EVs) enhance recovery in models of acute kidney injury.
- In human kidney cells and organoids, USC-EVs increased proliferation, reduced cytotoxicity, and lowered oxidative stress after cisplatin-induced damage.
- In a mouse model of kidney injury, USC-EVs improved pathology and decreased the injury marker KIM-1.
- USC-EVs contain miRNAs that target pathways promoting epithelial cell proliferation, migration, and MAPK signaling, leading to increased ERK1/2 phosphorylation.
- The study indicates that the therapeutic benefits of urine-derived stem cells are largely mediated by their extracellular vesicles, supporting further development as a treatment for acute kidney injury.