Notch Signaling Exacerbates Pulmonary Fibrosis by Regulating the Differentiation of CD4+ Tissue-Resident Memory T Cells - PubMed
5 hours ago
- #Notch signaling
- #pulmonary fibrosis
- #CD4+ TRM cells
- CD4+ tissue-resident memory T (TRM) cells are found at higher frequencies in fibrotic lung tissue and correlate with disease severity.
- These CD4+ TRM cells exhibit a pro-inflammatory and pro-fibrotic phenotype, and their depletion alleviates fibrosis.
- CD4+ TRM cells primarily originate from recruited circulating lymphocytes; blocking this recruitment reduces TRM accumulation and attenuates disease.
- The Notch signaling pathway is activated in fibrotic lung CD4+ TRM cells, and its inhibition suppresses their differentiation and pro-fibrotic function.
- The study suggests CD4+ TRM cells are pathogenic drivers in pulmonary fibrosis and highlights their potential as therapeutic targets.