SOX4 induces cisplatin resistance in cervical cancer cells by inhibiting aerobic glycolysis - PubMed
5 hours ago
- #Cisplatin resistance
- #Cervical cancer
- #SOX4
- SOX4 induces cisplatin resistance in cervical cancer cells by inhibiting aerobic glycolysis.
- SOX4 also induces resistance to oxaliplatin and carboplatin, suggesting its role as a multidrug resistance gene.
- Overexpression of SOX4 suppresses glycolytic activity and inhibits both intrinsic and extrinsic apoptotic pathways.
- SOX4 upregulates SIRT1, which represses GLUT1 expression, leading to reduced glucose uptake and glycolysis.
- SOX4-driven metabolic deceleration helps cancer cells evade cisplatin-mediated cytotoxicity.
- The findings highlight SOX4's role in cisplatin resistance via SIRT1-mediated glycolysis suppression.