Bifunctional Peptide Amphiphile Hydrogel Orchestrates Concerted Antioxidant and Anti-Inflammatory Actions to Counter Myocardial Ischemia/Reperfusion Injury - PubMed
5 hours ago
- #Injectable Hydrogel
- #Antioxidant Therapy
- #Myocardial Ischemia-Reperfusion Injury
- T&A-Gel is a supramolecular peptide amphiphile hydrogel that integrates α-tocopherol and Angiotensin-(1-7) for co-delivery.
- It simultaneously addresses oxidative stress and inflammation in myocardial ischemia/reperfusion injury by scavenging reactive oxygen species and activating the MasR/PI3K/Akt pathway.
- In vitro and in vivo results show enhanced cardiomyocyte viability, reduced infarct size, and improved cardiac function with excellent biocompatibility.