Comparative efficacy and safety of Chinese botanical drug injection in patients with sepsis: A systematic review and Bayesian network meta-analysis of randomized clinical trials - PubMed
8 hours ago
- #Network Meta-Analysis
- #Sepsis
- #Botanical Drug Injection
- Huangqi injection combined with Western Medical Treatments (WMT) shows the best improvement in APACHE II scores and 28-day mortality rates for sepsis patients.
- Tanreqing injection significantly reduces procalcitonin (PCT) levels, while Shenmai injection is most effective in lowering C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) levels.
- Xuebijing injection is highlighted for its effectiveness in reducing white blood cell counts (WBC) in sepsis treatment.
- The study is a Bayesian network meta-analysis of 72 randomized controlled trials involving 6,351 participants, assessing seven Chinese botanical drug injections (CBDIs) alongside WMT.
- Authors conclude that certain CBDIs demonstrate enhanced efficacy and safety, advocating for their integration into sepsis management, but call for further large-scale trials to validate findings.