Betulinic acid induces lysosome-dependent death in prostate cancer by targeting DDX5 - PubMed
7 hours ago
- #lysosome-dependent death
- #prostate cancer
- #betulinic acid
- Betulinic acid (BA) shows antitumor effects in prostate cancer (PCa) by directly binding to DDX5.
- This binding inhibits transcription factor EB (TFEB)-mediated lysosomal biogenesis and reduces V-ATPase subunit H (ATP6V1H) expression, disrupting lysosomal acidification.
- Disruption leads to lysosomal membrane permeabilization (LMP) and lysosome-dependent cell death (LDCD) via apoptosis, which is dependent on DDX5.
- BA suppresses PCa growth in vitro and in vivo without toxicity, and DDX5 expression is decreased in PCa tissues.
- The findings suggest BA's therapeutic potential and propose lysosomal membrane destabilization as a precision treatment strategy for PCa.