Individualized precision therapy for severe asthma: clinical applications of biological agents and frontiers of cell therapy - PubMed
6 hours ago
- #precision medicine
- #cell therapy
- #asthma
- Asthma management has shifted to precision medicine guided by phenotypes, using targeted biologics for pathways like IgE, IL-5/IL-5R, IL-4/IL-13, and TSLP.
- Current biologics face challenges like long-term administration and inability to reverse disease progression, driving interest in next-generation therapies.
- Cell therapy offers transformative potential by moving from passive suppression to active regulation, with approaches including cellular reprogramming (e.g., Th2 to Treg cells), engineering (e.g., CAR-NK cells), and multifunctional modulation (e.g., MSCs and exosomes).
- Future asthma management aims for long-term immune tolerance or functional cure through integrated systems combining biologics, advanced cell therapies, and precision strategies.