Metabolic Liver Disease Beyond the Liver: Association of Metabolic Dysfunction-Associated Steatotic Liver Disease with Cardiovascular and Renal Diseases - PubMed
6 hours ago
- #Chronic Kidney Disease
- #MASLD
- #Cardiovascular Disease
- MASLD is redefined as a systemic disorder with strong bidirectional associations with cardiovascular disease (CVD) and chronic kidney disease (CKD).
- Shared risk factors include obesity, insulin resistance, hypertension, and dyslipidemia.
- Common pathogenic mechanisms involve hepatic steatosis and inflammation leading to insulin resistance, atherogenic dyslipidemia, endothelial dysfunction, and a pro-inflammatory/prothrombotic environment.
- Hepatic contributions accelerate cardiovascular injury.
- The text includes disclosures from authors regarding advisory boards, consulting, lecture fees, and research grants from various pharmaceutical companies.