Chemo-photothermal synergy ignites antitumor immunity via ferroptosis - PubMed
6 hours ago
- #immunotherapy
- #photothermal therapy
- #ferroptosis
- Development of amphiphilic ferrocene-based polymer (PPEGMA-b-PFMMA) to co-encapsulate Docetaxel (Doc) and photosensitizer IR808, forming photothermally responsive nanoparticles (P8D NPs).
- P8D NPs improve aqueous stability and tumor-specific accumulation via hydrogen peroxide (H₂O₂)-triggered drug release in the tumor microenvironment.
- Near-infrared (NIR) irradiation causes P8D NPs to generate heat and reactive oxygen species (ROS), promoting drug release and nanoparticle disintegration.
- Doc induces HMGB1 translocation from nucleus to cytoplasm, while PTT/PDT facilitates extracellular release of DAMPs and tumor-associated antigens via ferroptosis and cell membrane rupture.
- Enhanced dendritic cell (DC) maturation, antigen presentation, and cytotoxic CD8+ T cell infiltration reverse the immunosuppressive tumor microenvironment.
- Combination strategy inhibits distant tumor growth and establishes long-term anti-tumor immunological memory to prevent recurrence.
- Ferrocene-based nanocarrier-mediated PTT/PDT synergizes with Doc to reactivate antitumor immunity through ferroptosis-induced immunogenic cell death (ICD).