Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor - PubMed
5 hours ago
- #complexin
- #neuromuscular junction
- #constitutive exocytosis
- Complexin regulates both constitutive and activity-dependent exocytosis of postsynaptic receptors.
- Loss of CPX-1 in C. elegans increases spontaneous miniature postsynaptic current amplitude independently of extracellular Ca2+.
- Postsynaptic expression of CPX-1 rescues the mPSC phenotype, indicating a postsynaptic role.
- Enhanced mPSC amplitude requires nicotinic acetylcholine receptor subunit ACR-16, which is elevated in cpx-1 mutants.
- UNC-31/CAPS is necessary for the increased mPSC amplitude and elevated ACR-16 expression in cpx-1 mutants.
- CPX-1 is involved in activity-dependent exocytosis of postsynaptic ACR-16.