Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer - PubMed
5 hours ago
- #Triple-negative breast cancer
- #Extracellular matrix
- #Jagged1
- Jagged1 regulates extracellular matrix (ECM) deposition and remodeling in triple-negative breast cancer (TNBC).
- High Jagged1 expression correlates with poor patient survival and promotes tumor growth and invasion in TNBC.
- Jagged1-mediated cross-talk between TNBC cells and fibroblasts enhances myofibroblast activation, collagen accumulation, and ECM fiber alignment.
- Jagged1 increases transforming growth factor-β (TGFβ) activity in fibroblast cocultures, and TGFβ inhibition prevents Jagged1-induced ECM alignment.
- Higher substrate stiffness up-regulates Jagged1, suggesting a feed-forward loop between Jagged1, ECM stiffness, and TGFβ.
- Targeting Jagged1 may offer a therapeutic approach for treating invasive breast cancer.