Nutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis - PubMed
6 hours ago
- #Nutritional Supplements
- #Cognitive Function
- #Mild Cognitive Impairment
- Nutritional supplementation is considered a potential strategy to preserve or enhance cognitive function in healthy aging and mild cognitive impairment (MCI) patients.
- Docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) + vitamin E + tryptophan + melatonin, and melatonin alone, significantly enhance global cognitive function.
- DHA, folic acid + DHA, and DHA + EPA + vitamin E + tryptophan + melatonin improve memory.
- DHA alone benefits processing speed, while vitamin D3 improves visuospatial function.
- Folic acid, vitamin B12, and vitamin B6 supplementation improve blood biomarkers like homocysteine, vitamin B12, and serum folate levels.
- Nutritional supplementation shows domain-specific benefits rather than universal cognitive enhancement, influenced by baseline cognitive status, age, and intervention duration.
- Personalized nutritional strategies and further high-quality, longitudinal trials are needed to confirm long-term clinical impact.