Efficacy of Glucagon-Like Peptide-1 Receptor Agonists for Psychological Well-Being and Depressive Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - PubMed
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- #Meta-analysis
- #Psychological Well-being
- #GLP-1RA
- GLP-1RAs show a small but significant improvement in psychological well-being (SMD = 0.374), but no significant effect on depressive symptoms (SMD = 0.079).
- Improvements in psychological well-being were observed with specific GLP-1RAs (semaglutide, tirzepatide, liraglutide), subcutaneous administration, and in populations with type 2 diabetes or obesity.
- The psychological benefits are likely indirect, reflecting improvements in metabolic status or general health rather than direct mood effects.