Hyperglutaminolysis drives senescence and aging through arginine-mTORC1 axis activation - PubMed
5 days ago
- #aging
- #mTORC1
- #glutaminolysis
- Hyperglutaminolysis is hyperactivated in senescent cells and aged organisms like Drosophila and mice.
- This hyperactivation promotes aging, as shown by addition and removal intervention experiments.
- A novel signaling axis links hyperglutaminolysis to persistent mTORC1 activation via ammonium, glutamate, and arginine biosynthesis.
- Key enzymes GLS1 and ASL play regulatory roles in this cascade, verified by cellular and in vivo experiments.
- Dysregulated glutaminolysis is identified as a key driver of aging, connecting glutamine catabolism to mTORC1 activation.