CRLF1 Secreted by Cardiac Fibroblasts Promotes Human Hypertrophic Cardiomyopathy - PubMed
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- #CRLF1
- #Cardiac Fibroblasts
- #Hypertrophic Cardiomyopathy
- CRLF1, secreted by cardiac fibroblasts, promotes hypertrophic cardiomyopathy (HCM).
- HCM is a common inherited cardiac disorder and a leading cause of sudden cardiac death in young adults.
- Nearly half of HCM patients lack identifiable genetic defects, suggesting undiscovered mechanisms.
- CRLF1 levels are elevated in hypertrophied myocardium and circulation, activating the LIFR-JAK1/2-STAT3 signaling cascade.
- Genetic ablation of Crlf1 or pharmacological inhibition of its pathway attenuates disease phenotypes.
- CRLF1 is identified as a universal therapeutic target for HCM.